Genome-wide study of methotrexate clearance replicates SLCO1B1
نویسندگان
چکیده
منابع مشابه
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with ALL, we identified SLCO1B1 as harboring multiple common polymorphisms associated with methotrexate...
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ژورنال
عنوان ژورنال: Blood
سال: 2013
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-08-452839